{"id":1080,"date":"2020-01-13T19:11:05","date_gmt":"2020-01-13T19:11:05","guid":{"rendered":"https:\/\/www.eterateam.com\/rs\/?p=1080"},"modified":"2026-02-01T01:27:40","modified_gmt":"2026-01-31T23:27:40","slug":"sta-su-maticne-celije","status":"publish","type":"post","link":"https:\/\/www.eterateam.com\/rs\/sta-su-maticne-celije\/","title":{"rendered":"\u0160ta Su Mati\u010dne \u0106elije ?"},"content":{"rendered":"

\u0160ta su mati\u010dne \u0107elije i kako se dobijaju?<\/h3>\n

Svake godine sve vi\u0161e i vi\u0161e ljudi govori o mati\u010dnim \u0107elijama: koriste se u raznim oblastima medicine, kao i u kozmetologiji. Ali \u0161ta su mati\u010dne \u0107elije, odakle dolaze i da li svi imaju pristup ovom jedinstvenom lekovitom resoru?<\/p>\n

\u0160ta su mati\u010dne \u0107elije?<\/h3>\n

To su takozvane “nezrele” ili nediferencirane \u0107elije koje se nalaze u telu svakog \u017eivog vi\u0161e\u0107elijskog bi\u0107a. Odnosno, telo svakog sisara, uklju\u010duju\u0107i ljude, opremljeno je odre\u0111enom \u201erezervom\u201c mati\u010dnih \u0107elija. Njihove glavne karakteristike su sposobnost samoobnavljanja i formiranja novih istih \u0107elija, deljenja i tako\u0111e preuzimanja funkcija bilo kog tkiva i organa (to se naziva diferencijacija \u0107elija). Prvi put se pojam “mati\u010dna \u0107elija” po\u010deo da koristi 1909. Ulogu ovih \u0107elija prou\u010davali su nau\u010dnici u mnogim zemljama sveta tokom skoro celog dvadesetog veka, neprekidno dopunjavaju\u0107i saznanja o ulozi mati\u010dnih \u0107elija u telu i mogu\u0107nostima njihove upotrebe. Tako\u0111e se koristi i termin \u201eautologne\u201c (sopstvene) mati\u010dne \u0107elije.<\/p>\n

Iz mati\u010dnih \u0107elija u periodu razvoja fetusa formiraju se svi unutra\u0161nji organi, krvni sudovi, ko\u017ea i sva ostala tkiva. Po\u0161to se proces diferencijacije \u0107elija odvija pre ro\u0111enja, najve\u0107i broj mati\u010dnih \u0107elija nalazi se u organizmu u razvoju, a do ro\u0111enja ve\u0107ina mati\u010dnih \u0107elija se skladi\u0161ti u krvi iz pup\u010dane vrpce, tkivu pup\u010dane vrpce i placenti.
\nU telu odrasle osobe se tako\u0111e nalaze mati\u010dne \u0107elije. Ovo je svojevrsni “komplet za popravku” koji telo koristi da bi pomoglo obnavljanju i obnavljanju organa i tkiva. Ali \u0161to je starija osoba, to je manje mati\u010dnih \u0107elija i manje su mogu\u0107nosti da \u201epopravite\u201c pogo\u0111eni organ. Smanjenje broja mati\u010dnih \u0107elija i usporavanje njihove proizvodnje od strane tela prirodan je proces koji je deo procesa fizi\u010dkog starenja.<\/p>\n<\/div>

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Le\u010denje mati\u010dnim \u0107elijama<\/h3>\n

U 70 godinama dvadesetog veka, pomla\u0111ivanje mati\u010dnih \u0107elija postalo je veoma popularno – \u201eInekcije mladih\u201c, koje su samo izuzetno bogatim osobama evrope, amerike i nomenklatura sovjetske stranke mogli sebi da priu\u0161te. To su osobe koje nisu \u017eelele da podlegnu uticaju starosti, a imali su dovoljno finasijskih sredstava, da im se ubrizgaju (presa\u0111uju) mati\u010dne \u0107elije da bi se aktivirali procesi pomla\u0111ivanja tela. Danas se preparati mati\u010dnih \u0107elija aktivno koriste u kozmetologiji i gerontologiji.<\/p>\n

Potencijal biologije biolo\u0161kih mati\u010dnih \u0107elija u le\u010denju mnogih bolesti, uklju\u010duju\u0107i ozbiljne i one koje su ranije smatrane neizle\u010dive, od velikog su interesa i perspektive za nauku. Lista ovih bolesti dose\u017ee nekoliko desetina.<\/p>\n

Terapija mati\u010dnim \u0107elijama<\/a> otvara velike mogu\u0107nosti u rekonstruktivnoj medicini. U mnogim zemljama sveta, uklju\u010duju\u0107i Ukrajinu, oni se koriste u le\u010denju hemijskih i termi\u010dkih opekotina visokog stepena . Zahvaljuju\u0107i sposobnosti mati\u010dnih \u0107elija da se diferenciraju u \u0107elije bilo kog telesnog tkiva, poma\u017eu u obnavljanju o\u0161te\u0107ene ko\u017ee na velikim povr\u0161inama. Ako se koriste autologne mati\u010dne \u0107elije, ne postoji rizik odbacivanja uz upotrebu materijala donora.<\/p>\n<\/div>

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\"mati\u010dne<\/span><\/div>
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Drugo obe\u0107avaju\u0107e podru\u010dje primene mati\u010dnih \u0107elija je kardiologija.<\/strong> U Ukrajini su u toku njihova klini\u010dka ispitivanja za ishemijsku kardiomiopatiju, oslabljenu sr\u010danu kontraktilnost. Preparat iz mati\u010dnih \u0107elija mo\u017ee pomo\u0107i pacijentima sa ozbiljnim sr\u010danim abnormalnostima da pre\u017eive u i\u0161\u010dekivanju transplantacije srca.
\nTako\u0111e, primenjuju se u le\u010denju, terapije mati\u010dnih \u0107elija, za cirozu jetre<\/strong>; lekari u Ukrajini i drugim zemljama ve\u0107 imaju praksu uspe\u0161nog kori\u0161\u0107enja biolo\u0161kog proizvoda za te\u0161ke patologije pankreasa.<\/strong><\/p>\n

Upotreba nediferenciranih \u0107elija mo\u017ee produ\u017eiti \u017eivot i zna\u010dajno pobolj\u0161ati njegov kvalitet za osobe sa dijabetesom<\/strong>. Poznato je da se s ovom bole\u0161\u0107u razvijaju vaskularne lezije razli\u010dite te\u017eine, koje izazivaju trofi\u010dne \u010direve na nogama, takozvano “dijabeti\u010dko stopalo” i arterije.<\/strong><\/p>\n

U zavr\u0161noj fazi su u toku klini\u010dka ispitivanja pripreme mati\u010dnih \u0107elija za ove patologije. Sve ove studije su sprovedene u Ukrajini.<\/p>\n

Tako\u0111e, dobijeni su mnogi pozitivni rezultati primene mati\u010dnih \u0107elija u le\u010denju multiple skleroze, Crohnove bolesti, Parkinsonove bolesti, zatajenja srca, reumatoidnog artritisa, leukemije i malignih tumora razli\u010ditih lokacija.<\/strong><\/p>\n<\/div>

Ljudske mati\u010dne \u0107elije:<\/h3>\n

Mati\u010dne \u0107elije su razli\u010dite u zavisnosti od porekla, odnosno u zavisnosti od izvora materijala. Pored mati\u010dnih \u0107elija embriona i fetusa, \u010dije primanje ima ozbiljna eti\u010dka ograni\u010denja, postoji i mogu\u0107nost izolacije “nezrelih” \u0107elija bez ikakvog o\u0161te\u0107enja tela, koje nije u suprotnosti sa moralnim i eti\u010dkim standardima. Tako dobijene mati\u010dne \u0107elije uklju\u010duju:<\/p>\n

Postnatalne (\u201eodrasle\u201c) mati\u010dne \u0107elije.<\/strong> To su \u0107elije odraslog tela koje se, kao \u0161to je ve\u0107 spomenuto, sadr\u017ee u njemu i stvaraju u malim koli\u010dinama. Problem je \u0161to su takve \u0107elije \u010desto u odre\u0111enoj fazi diferencijacije, a to zna\u010dajno smanjuje mogu\u0107nost njihove upotrebe.<\/p>\n

Me\u0111utim, postoje i prednosti: mogu se dobiti autologne postnatalne mati\u010dne \u0107elije, \u0161to zna\u010di da ih primalac ne\u0107e odbiti nakon transplantacije, jer je to njegov vlastiti biolo\u0161ki materijal.<\/p>\n

Mati\u010dne \u0107elije krvi iz pupkovine.<\/strong> Pripadaju postnatalnim mati\u010dnim \u0107elijama, ali od svih \u0107elija odraslog zrelog organizma su najmanje diferencirane. To zna\u010di da se, ako je potrebno, mogu koristiti za \u0161irok spektar bolesti, u gerontologiji, rehabilitacionoj medicini, jer imaju najve\u0107i potencijal \u201epopravljanja\u201c, razli\u010du\u0107i se u \u0107elije onih organa ili tkiva koje je potrebno \u201epopraviti\u201c.<\/p>\n<\/div>

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U zavisnosti od \u201ezadataka\u201c koje nezrele \u0107elije tela mogu da izvr\u0161avaju, dele se u tri vrste:<\/p>\n

Hematopoetske mati\u010dne \u0107elije<\/strong> se tako\u0111e nazivaju hematopoetskih, jer se diferenciraju u \u0107elije krvi. Nalaze se i u krvi iz pup\u010dane vrpce i u ko\u0161tanoj sr\u017ei – \u010desto se koriste za transplantaciju u slu\u010daju malignih krvnih bolesti.<\/p>\n

Mezenhimske mati\u010dne \u0107elije<\/strong> nazivaju se stromalne i multipotentne. Njihova karakteristika je sposobnost diferencijacije u \u0107elije ko\u0161tanog, hrskavi\u010dnog i masnog tkiva. Ove \u0107elije su izolovane iz krvi iz pup\u010dane vrpce, pup\u010dane vrpce i placente. Aktivno se primenjuju u le\u010denju dijabeti\u010dkog stopala (ozbiljna komplikacija \u0161e\u0107erne bolesti, pri obnovi ko\u017ee), kao i bolesti mi\u0161i\u0107no-ko\u0161tanog sistema, posebno zglobova.<\/p>\n

\u0106elije specifi\u010dne za tkivo su potomke, to jest “\u0107elije progenitora”<\/strong>. Sadr\u017ee se u organima i tkivima, telo ih aktivira ako je potrebno da a\u017eurira \u0107elijsku masu odre\u0111enog organa ili tkiva. Za razliku od ostalih nediferenciranih mati\u010dnih \u0107elija, koje se mogu podijeliti neograni\u010den broj puta, \u0107elije specifi\u010dne za tkivo nemaju tu sposobnost<\/p>\n<\/div>

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